CDKL1

Across TCGA patient cohorts, CDKL1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,210 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDKL1-associated proteins across cancer lineages are CALR, RPS6, and ARID3A_S119. Each is linked with CDKL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDKL1-to-partner and partner-to-CDKL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDKL1 versus CALR in GBM, with a Pearson correlation of -0.28.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDKL1→partner) and Y-score (partner→CDKL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CALR →	-0.302	-0.380	<.001	.001	3	5
GBM	RPS6 →	-0.453	-0.441	<.001	<.001	3	5
BRCA	ARID3A_S119 →	-0.792	-0.376	<.001	<.001	3	5
BRCA	SRPRA →	-0.304	-0.296	<.001	<.001	3	5
GBM	SSRP1 →	+0.399	+0.386	.002	.002	3	4
GBM	SUPT16H →	+0.365	+0.424	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,210 associations by consensus.

CDKL1 vs CALR — GBM

Explore this scatter interactively →