CDK9

Across TCGA patient cohorts, CDK9 mutation is significantly associated with the RNA expression of many other genes, with 689 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK9-associated genes across cancer lineages are LINC02590, AKIRIN1P2, and MIR6796. Each is linked with CDK9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK9-to-partner and partner-to-CDK9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC02590 grouped by CDK9-low versus CDK9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK9→partner) and Y-score (partner→CDK9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	LINC02590 →	+0.218	+3.515	<.001	.005	3	2
SKCM	AKIRIN1P2 →	+0.215	+3.875	<.001	.008	3	2
LIHC	MIR6796 →	+0.395	+4.268	<.001	.001	3	1
LIHC	FAM223A →	+0.029	+4.305	<.001	.007	3	1
SKCM	RN7SL680P →	+0.227	+5.634	<.001	.001	3	1
LIHC	RNA5SP54 →	+0.299	+4.902	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 689 associations by consensus.

LINC02590 by CDK9 expression — COAD

Explore this box plot interactively →