CDK8

Across TCGA patient cohorts, CDK8 protein abundance is significantly associated with the protein abundance of many other proteins, with 17,927 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK8-associated proteins across cancer lineages are SIN3A_S860, BUB1B, and C16orf89. Each is linked with CDK8 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDK8-to-partner and partner-to-CDK8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK8 versus SIN3A_S860 in BRCA, with a Pearson correlation of 0.38.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK8→partner) and Y-score (partner→CDK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SIN3A_S860 →	+0.659	+0.617	<.001	<.001	3	5
OV	BUB1B →	+1.472	+1.454	<.001	<.001	3	4
UCEC	C16orf89 →	-1.780	-0.602	.002	<.001	3	4
BRCA	CDK11B →	+0.375	+0.587	<.001	<.001	3	4
LUAD	CHD7_S2956 →	+0.638	+0.269	.001	.002	2	5
LSCC	PPP1R10 →	+0.271	+0.394	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,927 associations by consensus.

CDK8 vs SIN3A_S860 — BRCA

Explore this scatter interactively →