CDK8

Across TCGA patient cohorts, CDK8 mutation is significantly associated with the RNA expression of many other genes, with 2,438 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK8-associated genes across cancer lineages are PRKACG, HMGB3P11, and MAPK6P6. Each is linked with CDK8 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK8-to-partner and partner-to-CDK8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKACG grouped by CDK8-low versus CDK8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK8→partner) and Y-score (partner→CDK8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PRKACG →	+0.033	+3.379	.004	.007	3	2
LUAD	HMGB3P11 →	+0.123	+3.445	<.001	.006	3	2
LUAD	MAPK6P6 →	+0.108	+4.679	<.001	<.001	3	2
LUAD	RPL35AP3 →	+0.128	+3.613	.001	.006	3	2
LUAD	PHOX2B-AS1 →	+0.141	+3.888	.007	.004	3	2
LUAD	FAM30C →	+0.091	+4.315	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,438 associations by consensus.

PRKACG by CDK8 expression — LUAD

Explore this box plot interactively →