CDK7

Across TCGA patient cohorts, CDK7 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK7-associated genes across cancer lineages are eIF4E, INPP4B, and JNK_pT183_Y185. Each is linked with CDK7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK7-to-partner and partner-to-CDK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CDK7-low versus CDK7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK7→partner) and Y-score (partner→CDK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.215	+2.222	.016	.011	3	1
UCEC	INPP4B →	-0.379	-3.584	.005	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.214	-2.459	.002	.019	3	1
UCEC	Ku80 →	+0.306	+2.920	.002	.001	3	1
UCEC	MEK1 →	+0.424	+3.700	.006	.001	3	1
UCEC	mTOR_pS2448 →	-0.209	-2.565	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eIF4E by CDK7 expression — UCEC

Explore this box plot interactively →