CDK7

Across TCGA pan-cancer cohorts, CDK7 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CDK7 data layer compared with 1 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CDK7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDK7 expression acts as an unfavorable survival marker, although some lineages such as KIRC and BLCA show a favorable association.

HNSC, KICH, and LIHC are the cancer types where CDK7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.653	0.764	.004	100	view →
KICH	DFS	Median	All	0.766	1.000	.001	85	view →
LIHC	DFS	Median	All	0.463	0.618	<.001	80	view →
KIRP	DFS	Median	All	0.785	0.915	<.001	60	view →
KIRC	DFS	Median	III,IV	0.786	0.488	<.001	52	view →
LGG	OS	Median	All	0.741	0.881	<.001	47	view →
UVM	DFS	Tertile	All	0.341	0.733	.008	36	view →
PAAD	OS	Median	All	0.298	0.475	.004	34	view →
UCS	DFS	Quartile	II,III,IV	0.165	0.711	.015	32	view →
LUAD	OS	Median	All	0.269	0.461	.006	31	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	28	view →
OV	DFS	Median	IV	0.230	0.378	.031	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CDK7–HNSC (DFS)

Open the HNSC breakdown →