CDK7

Across TCGA cell cohorts, CDK7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,980 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CDK7-associated GO terms across cancer lineages are Regulation of phospholipid translocation, Positive regulation of phospholipid translocation, and Monoubiquitinated protein deubiquitination. Each is linked with CDK7 in more than 8 cancer types. Because this analysis shows association rather than direction, both CDK7-to-partner and partner-to-CDK7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of phospholipid translocation grouped by CDK7-low versus CDK7-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK7→partner) and Y-score (partner→CDK7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of phospholipid translocation →	+0.165	+0.679	.005	.003	3	9
BONE	Positive regulation of phospholipid translocation →	+0.165	+0.679	.005	.003	3	9
BLOOD_Lymphoma	Monoubiquitinated protein deubiquitination →	+0.099	+0.735	<.001	<.001	3	9
BONE	Clathrin-coated vesicle cargo loading →	+0.122	+0.731	.001	.003	3	8
BONE	Clathrin-coated vesicle cargo loading, AP-3-mediated →	+0.122	+0.731	.001	.003	3	8
BONE	Positive regulation of ligase activity →	+0.114	+0.744	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,980 associations by consensus.

Regulation of phospholipid translocation by CDK7 expression — BONE

Explore this box plot interactively →