CDK6

Across TCGA patient cohorts, CDK6 protein abundance is significantly associated with the RNA expression of many other genes, with 12,013 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CDK6-associated genes across cancer lineages are CDK6-AS1, RNU6-10P, and CLGN. Each is linked with CDK6 in more than 6 cancer types. Because this analysis shows association rather than direction, both CDK6-to-partner and partner-to-CDK6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK6 versus CDK6-AS1 in GBM, with a Pearson correlation of 0.67.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK6→partner) and Y-score (partner→CDK6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CDK6-AS1 →	+1.204	+1.165	<.001	<.001	3	7
GBM	RNU6-10P →	+1.277	+1.317	<.001	<.001	3	5
BRCA	CLGN →	-1.606	-0.554	<.001	<.001	3	4
UCEC	RAB11FIP4 →	-0.650	-0.319	.004	.004	3	4
BRCA	WDR31 →	-0.753	-0.477	<.001	<.001	3	4
UCEC	SLC50A1 →	-0.521	-0.350	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,013 associations by consensus.

CDK6 vs CDK6-AS1 — GBM

Explore this scatter interactively →