CDK6-AS1

Across TCGA pan-cancer cohorts, CDK6-AS1 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CDK6-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CDK6-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDK6-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

KIRC, BLCA, and MESO are the cancer types where CDK6-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.550	0.698	<.001	136	view →
BLCA	OS	Median	All	0.343	0.551	<.001	128	view →
MESO	OS	Tertile	All	0.395	0.656	.001	71	view →
THCA	OS	Median	All	0.979	1.000	<.001	68	view →
UVM	OS	Quartile	All	0.869	0.404	<.001	61	view →
ACC	DFS	Tertile	II,III,IV	0.307	0.655	.001	50	view →
UCEC	OS	Quartile	All	0.534	0.821	<.001	48	view →
LGG	DFS	Tertile	All	0.633	0.782	<.001	37	view →
KIRP	DFS	Tertile	All	1.000	0.424	<.001	35	view →
UCS	DFS	Quartile	II,III,IV	0.598	0.227	.016	32	view →
LAML	DFS	Quartile	All	0.869	0.439	<.001	30	view →
LUAD	OS	Quartile	II,III,IV	0.583	0.763	.007	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CDK6-AS1–KIRC (DFS)

Open the KIRC breakdown →