CDK6-AS1

Across TCGA pan-cancer cohorts, CDK6-AS1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CDK6-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CDK6-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDK6-AS1 is over-expressed in tumor, although a few such as KICH and UCEC show the opposite, repressed pattern.

HNSC, KICH, and UCEC are the cancer types where CDK6-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDK6-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+0.738	<.001	9	view →
KICH	Female	II,III,IV	−1.007	<.001	7	view →
UCEC	All	All	−0.593	<.001	6	view →
KIRC	Male	II,III,IV	−0.336	.001	6	view →
BRCA	All	All	−0.325	<.001	6	view →
THCA	All	II,III,IV	−0.207	<.001	6	view →
LUSC	Male	All	+0.387	<.001	5	view →
COAD	Male	II,III,IV	+0.355	.012	5	view →
LIHC	Male	All	+0.302	<.001	4	view →
READ	Male	All	+0.386	.019	2	view →
CHOL	All	All	+0.526	.032	1	view →
STAD	All	All	+0.303	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CDK6-AS1–HNSC

Open the HNSC breakdown →