CDK5RAP2

Across TCGA pan-cancer cohorts, CDK5RAP2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of CDK5RAP2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where CDK5RAP2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CDK5RAP2 is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where CDK5RAP2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDK5RAP2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	II,III,IV	+0.206	<.001	11	view →
PDAC	All	II,III,IV	−0.240	<.001	6	view →
LSCC	Female	All	−0.165	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

CDK5RAP2–CCRCC

Open the CCRCC breakdown →