CDK5RAP2

Across TCGA pan-cancer cohorts, CDK5RAP2 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CDK5RAP2 data layer compared with 9 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher CDK5RAP2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDK5RAP2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and MESO show a favorable association.

ACC, KIRC, and HNSC are the cancer types where CDK5RAP2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.345	0.810	<.001	119	view →
KIRC	DFS	Quartile	All	0.856	0.465	<.001	52	view →
HNSC	OS	Tertile	All	0.233	0.559	.001	50	view →
LGG	DFS	Median	All	0.785	0.879	<.001	36	view →
MESO	OS	Tertile	All	0.543	0.277	.001	32	view →
BLCA	DFS	Quartile	II,III,IV	0.451	0.591	.009	32	view →
LIHC	DFS	Median	All	0.464	0.617	<.001	29	view →
KIRP	DFS	Quartile	All	0.825	0.971	.004	28	view →
SCLC	OS	Median	All	0.772	0.504	.006	17	view →
GBM	DFS	Median	All	0.381	0.195	.004	14	view →
COAD	DFS	Median	All	0.736	0.825	.015	13	view →
UVM	DFS	Median	III,IV	0.280	0.619	.007	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CDK5RAP2–ACC (DFS)

Open the ACC breakdown →