CDK5RAP2

Across TCGA patient cohorts, CDK5RAP2 protein abundance is significantly associated with the RNA expression of many other genes, with 9,103 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK5RAP2-associated genes across cancer lineages are WDR5, MED22, and INCENP. Each is linked with CDK5RAP2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDK5RAP2-to-partner and partner-to-CDK5RAP2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK5RAP2 versus WDR5 in HNSC, with a Pearson correlation of 0.32.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP2→partner) and Y-score (partner→CDK5RAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	WDR5 →	+0.712	+0.235	.006	<.001	3	6
LSCC	MED22 →	+0.452	+0.166	<.001	<.001	3	5
OV	INCENP →	+0.884	+0.247	.002	.004	3	5
OV	NUP188 →	+0.870	+0.321	.001	<.001	3	5
OV	CAMSAP1 →	+0.614	+0.317	.005	<.001	3	5
LSCC	ODF2 →	+0.818	+0.362	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,103 associations by consensus.

CDK5RAP2 vs WDR5 — HNSC

Explore this scatter interactively →