CDK5RAP2

Across TCGA patient cohorts, CDK5RAP2 mutation is significantly associated with the RNA expression of many other genes, with 5,474 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5RAP2-associated genes across cancer lineages are TIMM22, NANS, and GRPEL1. Each is linked with CDK5RAP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDK5RAP2-to-partner and partner-to-CDK5RAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIMM22 grouped by CDK5RAP2-low versus CDK5RAP2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP2→partner) and Y-score (partner→CDK5RAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TIMM22 →	+0.580	+4.013	<.001	<.001	3	4
UCEC	NANS →	+0.384	+2.180	<.001	<.001	3	4
UCEC	GRPEL1 →	+0.402	+1.772	<.001	<.001	3	4
COAD	DENND10 →	+0.352	+2.249	.001	.006	3	4
UCEC	MED31 →	+0.401	+1.804	<.001	<.001	3	4
COAD	ZIC5 →	+0.840	+3.297	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,474 associations by consensus.

TIMM22 by CDK5RAP2 expression — COAD

Explore this box plot interactively →