CDK5RAP2

Across TCGA patient cohorts, CDK5RAP2 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5RAP2-associated genes across cancer lineages are TFRC, PCNA, and FoxM1. Each is linked with CDK5RAP2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDK5RAP2-to-partner and partner-to-CDK5RAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by CDK5RAP2-low versus CDK5RAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP2→partner) and Y-score (partner→CDK5RAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.432	+1.662	.002	.009	3	4
SKCM	PCNA →	+0.253	+3.000	.002	.034	3	3
UCEC	FoxM1 →	+0.149	+1.459	.032	.001	3	3
COAD	ASNS →	+0.642	+3.321	<.001	.009	3	3
UCEC	ATM →	-0.520	-1.628	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.317	+3.247	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

TFRC by CDK5RAP2 expression — UCEC

Explore this box plot interactively →