CDK5RAP2

Across TCGA cell cohorts, CDK5RAP2 mutation is significantly associated with the RNA expression of many other genes, with 774 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDK5RAP2-associated genes across cancer lineages are HELB, MRPL34, and ESYT1. Each is linked with CDK5RAP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK5RAP2-to-partner and partner-to-CDK5RAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELB grouped by CDK5RAP2-low versus CDK5RAP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5RAP2→partner) and Y-score (partner→CDK5RAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	HELB →	+0.478	+3.409	<.001	<.001	3	2
LARGE_INTESTINE	MRPL34 →	+0.416	+2.743	.005	.001	3	2
LARGE_INTESTINE	ESYT1 →	+0.517	+3.137	.004	.007	3	2
LARGE_INTESTINE	CFAP36 →	+0.505	+2.129	.008	.007	3	2
LARGE_INTESTINE	POMK →	+0.878	+2.459	.004	.006	3	2
LARGE_INTESTINE	HHLA3 →	+0.792	+2.829	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 774 associations by consensus.

HELB by CDK5RAP2 expression — LARGE_INTESTINE

Explore this box plot interactively →