CDK5R2

Across TCGA patient cohorts, CDK5R2 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5R2-associated genes across cancer lineages are GSK-3_pS9, GSK-3a-b_pS21_S9, and Ku80. Each is linked with CDK5R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK5R2-to-partner and partner-to-CDK5R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3_pS9 grouped by CDK5R2-low versus CDK5R2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5R2→partner) and Y-score (partner→CDK5R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	+0.388	+2.321	.046	.034	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.534	+2.331	.009	.019	3	1
UCEC	Ku80 →	+0.262	+2.820	.021	.035	3	1
UCEC	Di-Ras3 →	-0.181	-2.459	.011	.020	3	1
UCEC	JNK2 →	+0.398	+3.331	<.001	.005	2	1
UCEC	Tuberin →	+0.432	+3.009	<.001	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

GSK-3_pS9 by CDK5R2 expression — UCEC

Explore this box plot interactively →