CDK5R2

Across TCGA pan-cancer cohorts, CDK5R2 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CDK5R2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where CDK5R2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDK5R2 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

LUAD, KIRC, and HNSC are the cancer types where CDK5R2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDK5R2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	All	+0.658	<.001	8	view →
KIRC	Male	III,IV	+0.291	<.001	8	view →
HNSC	All	II,III,IV	+0.259	<.001	8	view →
COAD	Male	All	−0.629	<.001	7	view →
KIRP	All	All	+0.339	<.001	7	view →
UCEC	All	All	+0.376	<.001	6	view →
BRCA	All	All	+0.219	.002	6	view →
LUSC	Male	All	+0.579	<.001	5	view →
READ	All	All	−0.782	.008	2	view →
STAD	Female	III,IV	−1.555	.026	1	view →
CHOL	All	All	+0.382	.031	1	view →
THCA	All	IV	+0.047	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CDK5R2–LUAD

Open the LUAD breakdown →