CDK5R1

Across TCGA patient cohorts, CDK5R1 mutation is significantly associated with the RNA expression of many other genes, with 1,607 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK5R1-associated genes across cancer lineages are TMX2, DHFR, and YWHAEP5. Each is linked with CDK5R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK5R1-to-partner and partner-to-CDK5R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMX2 grouped by CDK5R1-low versus CDK5R1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5R1→partner) and Y-score (partner→CDK5R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMX2 →	+0.590	+3.210	<.001	.009	3	2
UCEC	DHFR →	+0.711	+2.459	<.001	<.001	3	2
COAD	YWHAEP5 →	+0.667	+3.237	<.001	.009	3	2
COAD	IGKV3D-34 →	+0.154	+3.917	<.001	.009	3	2
UCEC	CCDC43 →	+0.492	+2.491	<.001	<.001	3	2
UCEC	LRRC57 →	+0.425	+2.095	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,607 associations by consensus.

TMX2 by CDK5R1 expression — COAD

Explore this box plot interactively →