CDK5

Across TCGA pan-cancer cohorts, CDK5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CDK5 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CDK5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CDK5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and COAD show a favorable association.

CCRCC, UCEC, and LUAD are the cancer types where CDK5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.202	0.985	.007	27	view →
UCEC	DFS	Quartile	II,III,IV	1.000	0.366	.006	12	view →
LUAD	OS	Median	All	0.683	0.939	.014	9	view →
HNSC	DFS	Median	IV	0.548	0.816	.008	9	view →
COAD	DFS	Median	III,IV	1.000	0.844	.044	6	view →
LSCC	DFS	Median	All	0.892	1.000	.024	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CDK5–CCRCC (OS)

Open the CCRCC breakdown →