CDK5

Across TCGA patient cohorts, CDK5 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,433 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK5-associated proteins across cancer lineages are TNPO3, COPG2, and CUL1. Each is linked with CDK5 in more than 8 cancer types. Because this analysis shows association rather than direction, both CDK5-to-partner and partner-to-CDK5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK5 versus TNPO3 in LSCC, with a Pearson correlation of 0.57.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5→partner) and Y-score (partner→CDK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TNPO3 →	+0.282	+0.556	<.001	<.001	3	9
OV	COPG2 →	+0.304	+0.494	.009	.007	2	9
HNSC	CUL1 →	+0.284	+0.700	<.001	<.001	3	7
HNSC	RHEB →	+0.455	+0.734	<.001	<.001	3	7
LSCC	YWHAG →	+0.264	+0.533	<.001	<.001	3	6
GBM	GTF2I →	+0.597	+0.503	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,433 associations by consensus.

CDK5 vs TNPO3 — LSCC

Explore this scatter interactively →