CDK5

Across TCGA patient cohorts, CDK5 protein abundance is significantly associated with the RNA expression of many other genes, with 10,655 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK5-associated genes across cancer lineages are ACTR3B, METTL2B, and UBE3C. Each is linked with CDK5 in more than 8 cancer types. Because this analysis shows association rather than direction, both CDK5-to-partner and partner-to-CDK5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK5 versus ACTR3B in OV, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5→partner) and Y-score (partner→CDK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ACTR3B →	+0.649	+0.413	<.001	.001	3	8
OV	METTL2B →	+0.572	+0.455	<.001	<.001	3	8
OV	UBE3C →	+0.420	+0.377	.003	.004	2	9
UCEC	ATP6V0E2 →	+0.803	+0.196	<.001	<.001	3	8
CCRCC	MRPS33 →	+0.528	+0.303	<.001	<.001	3	8
CCRCC	SSBP1 →	+0.441	+0.329	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,655 associations by consensus.

CDK5 vs ACTR3B — OV

Explore this scatter interactively →