CDK5

Across TCGA cell cohorts, CDK5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,692 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CDK5-associated GO terms across cancer lineages are Negative regulation of synaptic vesicle exocytosis, Negative regulation of calcium ion-dependent exocytosis, and Nucleoside triphosphate biosynthetic process. Each is linked with CDK5 in more than 17 cancer types. Because this analysis shows association rather than direction, both CDK5-to-partner and partner-to-CDK5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of synaptic vesicle exocytosis grouped by CDK5-low versus CDK5-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK5→partner) and Y-score (partner→CDK5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Negative regulation of synaptic vesicle exocytosis →	+0.210	+1.136	<.001	<.001	3	18
KIDNEY	Negative regulation of calcium ion-dependent exocytosis →	+0.168	+0.635	.001	.003	3	12
BLOOD_Lymphoma	Nucleoside triphosphate biosynthetic process →	+0.071	+0.747	<.001	.001	3	11
BONE	Mitochondrial potassium ion transmembrane transport →	+0.139	+0.879	<.001	<.001	3	10
SKIN	Positive regulation of isotype switching to IgG isotypes →	+0.121	+0.908	<.001	<.001	3	10
LUNG_SCLC	Cytoskeleton-dependent cytokinesis →	+0.063	+0.568	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,692 associations by consensus.

Negative regulation of synaptic vesicle exocytosis by CDK5 expression — BLOOD_Myeloma

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