CDK2AP1

Across TCGA pan-cancer cohorts, CDK2AP1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CDK2AP1 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CDK2AP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDK2AP1 expression acts as an unfavorable survival marker, although some lineages such as SCLC and UCS show a favorable association.

KIRP, UVM, and KICH are the cancer types where CDK2AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	II,III,IV	0.407	0.818	<.001	111	view →
UVM	DFS	Tertile	All	0.316	0.731	<.001	83	view →
KICH	DFS	Tertile	III,IV	0.240	1.000	.001	64	view →
SCLC	DFS	Quartile	II,III,IV	0.700	0.296	.002	59	view →
HNSC	OS	Tertile	All	0.407	0.709	<.001	53	view →
UCS	OS	Median	II,III,IV	0.739	0.456	.017	42	view →
LIHC	DFS	Median	All	0.386	0.652	<.001	37	view →
LUAD	OS	Tertile	All	0.286	0.449	.003	31	view →
COAD	DFS	Tertile	All	0.682	0.849	.007	23	view →
ACC	DFS	Median	All	0.466	0.694	.007	14	view →
MESO	DFS	Median	II,III,IV	0.290	0.611	.006	14	view →
THCA	DFS	Tertile	All	0.915	0.770	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CDK2AP1–KIRP (DFS)

Open the KIRP breakdown →