CDK2AP1

Across TCGA pan-cancer cohorts, CDK2AP1 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CDK2AP1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CDK2AP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDK2AP1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, LUSC, and COAD are the cancer types where CDK2AP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDK2AP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.769	<.001	10	view →
LUSC	Female	All	+1.492	<.001	9	view →
COAD	Female	II,III,IV	+0.917	<.001	9	view →
LIHC	Female	All	+0.821	<.001	9	view →
BLCA	All	All	+0.616	<.001	9	view →
KIRC	All	All	+0.475	<.001	8	view →
LUAD	Male	II,III,IV	+0.634	<.001	7	view →
KIRP	All	III,IV	+0.666	.003	6	view →
STAD	All	II,III,IV	+0.633	.003	6	view →
UCEC	All	All	+0.604	.006	6	view →
CHOL	Male	All	+2.845	<.001	5	view →
BRCA	Female	All	+0.348	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CDK2AP1–HNSC

Open the HNSC breakdown →