CDK2AP1

Across TCGA pan-cancer cohorts, CDK2AP1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CDK2AP1 data layer compared with 26 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CDK2AP1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CDK2AP1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and GBM show a favorable association.

UCEC, HNSC, and LSCC are the cancer types where CDK2AP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.350	1.000	.006	32	view →
HNSC	DFS	Median	IV	0.625	0.901	.002	15	view →
LSCC	DFS	Tertile	All	1.000	0.914	.012	4	view →
GBM	OS	Median	All	0.545	0.270	.002	4	view →
CCRCC	DFS	Quartile	All	0.929	0.647	.046	2	view →
LUAD	OS	Median	All	0.971	0.918	.044	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CDK2AP1–UCEC (OS)

Open the UCEC breakdown →