CDK20

Across TCGA patient cohorts, CDK20 mutation is significantly associated with the RNA expression of many other genes, with 1,792 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK20-associated genes across cancer lineages are ZER1, SNORD116-5, and OR2A41P. Each is linked with CDK20 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK20-to-partner and partner-to-CDK20 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZER1 grouped by CDK20-low versus CDK20-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK20→partner) and Y-score (partner→CDK20) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZER1 →	+0.339	+3.191	.009	.009	3	2
STAD	SNORD116-5 →	+0.307	+5.506	<.001	.001	3	2
STAD	OR2A41P →	+0.393	+4.035	<.001	.004	3	2
CESC	TP53TG3GP →	+0.769	+5.103	<.001	.008	3	2
CESC	ARHGAP22-IT1 →	+0.089	+5.201	<.001	.007	3	2
CESC	RARRES2P6 →	+0.225	+5.201	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,792 associations by consensus.

ZER1 by CDK20 expression — UCEC

Explore this box plot interactively →