CDK2

Across TCGA patient cohorts, CDK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 20,907 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK2-associated proteins across cancer lineages are SMC4, MCM2, and MCM3. Each is linked with CDK2 in more than 9 cancer types. Because this analysis shows association rather than direction, both CDK2-to-partner and partner-to-CDK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK2 versus SMC4 in GBM, with a Pearson correlation of 0.74.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK2→partner) and Y-score (partner→CDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC4 →	+0.626	+0.644	<.001	<.001	3	10
GBM	MCM2 →	+0.772	+0.772	<.001	<.001	3	10
GBM	MCM3 →	+0.811	+0.784	<.001	<.001	3	10
GBM	MCM4 →	+0.778	+0.773	<.001	<.001	3	10
GBM	MCM5 →	+0.813	+0.735	<.001	<.001	3	10
GBM	MCM6 →	+0.907	+0.780	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,907 associations by consensus.

CDK2 vs SMC4 — GBM

Explore this scatter interactively →