CDK2

Across TCGA patient cohorts, CDK2 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK2-associated genes across cancer lineages are EGFR_pY1068, PDK1_pS241, and Shc_pY317. Each is linked with CDK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK2-to-partner and partner-to-CDK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CDK2-low versus CDK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK2→partner) and Y-score (partner→CDK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.299	-3.000	.039	.037	3	1
UCEC	PDK1_pS241 →	+0.263	+3.013	.007	.019	3	1
UCEC	Shc_pY317 →	-0.278	-3.000	.001	.036	3	1
UCEC	eIF4G →	+0.387	+3.000	.031	.037	2	1
UCEC	BRCA2 →	-0.194	-2.992	.008	.036	2	1
UCEC	Cyclin-B1 →	+0.777	+3.000	.016	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

EGFR_pY1068 by CDK2 expression — UCEC

Explore this box plot interactively →