CDK12

Across TCGA patient cohorts, CDK12 protein abundance is significantly associated with the protein abundance of many other proteins, with 25,474 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CDK12-associated proteins across cancer lineages are SNRNP70, TOX4, and CDK12_S423. Each is linked with CDK12 in more than 8 cancer types. Because this analysis shows association rather than direction, both CDK12-to-partner and partner-to-CDK12 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDK12 versus SNRNP70 in OV, with a Pearson correlation of 0.51.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK12→partner) and Y-score (partner→CDK12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SNRNP70 →	+0.638	+0.201	<.001	<.001	3	9
GBM	TOX4 →	+0.321	+0.205	<.001	.003	3	9
BRCA	CDK12_S423 →	+0.633	+0.528	<.001	<.001	3	9
GBM	IK →	+0.264	+0.214	<.001	<.001	3	9
LSCC	PPP1R10 →	+0.342	+0.329	<.001	<.001	3	9
GBM	SF3B1 →	+0.254	+0.196	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 25,474 associations by consensus.

CDK12 vs SNRNP70 — OV

Explore this scatter interactively →