CDK11B

Across TCGA patient cohorts, CDK11B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDK11B-associated genes across cancer lineages are eIF4E, ERK2, and JNK_pT183_Y185. Each is linked with CDK11B in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK11B-to-partner and partner-to-CDK11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CDK11B-low versus CDK11B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK11B→partner) and Y-score (partner→CDK11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.217	+2.459	.022	.019	3	1
UCEC	ERK2 →	+0.193	+2.999	.026	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.190	-2.687	.012	.006	3	1
UCEC	JNK2 →	+0.220	+2.000	.014	.032	3	1
UCEC	MEK1 →	+0.334	+3.321	.043	.010	3	1
UCEC	MSH6 →	-0.440	-2.999	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

eIF4E by CDK11B expression — UCEC

Explore this box plot interactively →