CDK11B

Across TCGA cell cohorts, CDK11B RNA expression is significantly associated with the go_rna of many other GO terms, with 4,136 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CDK11B-associated GO terms across cancer lineages are Regulation of telomerase RNA localization to Cajal body, Promoter clearance during DNA-templated transcription, and RNA polymerase II promoter clearance. Each is linked with CDK11B in more than 15 cancer types. Because this analysis shows association rather than direction, both CDK11B-to-partner and partner-to-CDK11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomerase RNA localization to Cajal body grouped by CDK11B-low versus CDK11B-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK11B→partner) and Y-score (partner→CDK11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of telomerase RNA localization to Cajal body →	+0.100	+0.723	.003	.002	3	16
URINARY_TRACT	Promoter clearance during DNA-templated transcription →	+0.131	+0.557	.001	.009	3	16
URINARY_TRACT	RNA polymerase II promoter clearance →	+0.131	+0.557	.001	.009	3	16
LUNG_SCLC	Response to methionine →	+0.117	+0.589	<.001	.001	3	16
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.221	+0.760	<.001	<.001	3	16
LUNG_SCLC	Cellular response to methionine →	+0.117	+0.589	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,136 associations by consensus.

Regulation of telomerase RNA localization to Cajal body by CDK11B expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →