CDK11B

Across TCGA cell cohorts, CDK11B mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDK11B-associated genes across cancer lineages are PRSS54, TRARG1, and TIFAB. Each is linked with CDK11B in more than 1 cancer types. Because this analysis shows association rather than direction, both CDK11B-to-partner and partner-to-CDK11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS54 grouped by CDK11B-low versus CDK11B-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK11B→partner) and Y-score (partner→CDK11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PRSS54 →	+0.038	+3.345	<.001	.007	3	1
LARGE_INTESTINE	TRARG1 →	+0.024	+4.345	<.001	<.001	3	1
LARGE_INTESTINE	TIFAB →	+0.004	+3.977	<.001	.001	3	1
LUNG_NSCLC_LUAD	CRYAA →	+0.124	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR51F2 →	+0.016	+4.662	<.001	.005	3	1
OVARY	ASB17 →	+0.023	+5.807	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PRSS54 by CDK11B expression — LARGE_INTESTINE

Explore this box plot interactively →