CDK11B

Across TCGA cell cohorts, CDK11B mutation is significantly associated with the mutation status of many other genes, with 1,113 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDK11B-associated genes across cancer lineages are TMEM260, GREB1, and CHFR. Each is linked with CDK11B in more than 2 cancer types. Because this analysis shows association rather than direction, both CDK11B-to-partner and partner-to-CDK11B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM260 grouped by CDK11B-low versus CDK11B-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDK11B→partner) and Y-score (partner→CDK11B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TMEM260 →	+4.339	+4.339	.009	.009	1	3
LARGE_INTESTINE	GREB1 →	+2.611	+4.372	<.001	<.001	1	3
OVARY	CHFR →	+4.415	+4.977	.007	.007	1	3
UPPER_AERODIGESTIVE_TRACT	COL4A1 →	+5.392	+5.392	.004	.004	1	3
UPPER_AERODIGESTIVE_TRACT	TMEM132A →	+5.392	+5.392	.004	.004	1	3
OVARY	CILP2 →	+4.415	+4.977	.007	.007	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,113 associations by consensus.

TMEM260 by CDK11B expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →