CDH8

Across TCGA patient cohorts, CDH8 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH8-associated genes across cancer lineages are INPP4B, ATM, and Caspase-7-cleavedD198. Each is linked with CDH8 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDH8-to-partner and partner-to-CDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by CDH8-low versus CDH8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH8→partner) and Y-score (partner→CDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.423	-3.584	.001	.002	3	4
UCEC	ATM →	-0.471	-1.947	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+0.780	+2.338	.006	.017	3	3
COAD	c-Myc →	-0.206	-2.321	.016	.032	3	3
UCEC	4E-BP1 →	+0.220	+2.321	.001	<.001	3	3
LUSC	VHL →	-0.748	-3.169	.019	.017	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

INPP4B by CDH8 expression — COAD

Explore this box plot interactively →