CDH8

Across TCGA cell cohorts, CDH8 mutation is significantly associated with the RNA expression of many other genes, with 2,169 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH8-associated genes across cancer lineages are PRB4, DCK, and GMCL1. Each is linked with CDH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDH8-to-partner and partner-to-CDH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRB4 grouped by CDH8-low versus CDH8-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH8→partner) and Y-score (partner→CDH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PRB4 →	+0.031	+4.017	.001	.007	3	3
LUNG_SCLC	DCK →	+0.676	+3.321	<.001	.004	3	3
LUNG_SCLC	GMCL1 →	+0.695	+3.321	<.001	.004	3	3
LARGE_INTESTINE	PPP2R5D →	+0.693	+2.743	<.001	.001	3	3
LARGE_INTESTINE	TAF5 →	+0.599	+3.850	<.001	<.001	3	3
LARGE_INTESTINE	DCAF16 →	+0.599	+2.916	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,169 associations by consensus.

PRB4 by CDH8 expression — OESOPHAGUS

Explore this box plot interactively →