CDH6

Across TCGA cell cohorts, CDH6 mutation is significantly associated with the RNA expression of many other genes, with 556 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH6-associated genes across cancer lineages are C10orf71, METTL8, and ZNF391. Each is linked with CDH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH6-to-partner and partner-to-CDH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C10orf71 grouped by CDH6-low versus CDH6-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH6→partner) and Y-score (partner→CDH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	C10orf71 →	+0.006	+4.906	<.001	.006	3	2
LARGE_INTESTINE	METTL8 →	+0.772	+3.502	.001	.001	3	2
LARGE_INTESTINE	ZNF391 →	+0.806	+3.169	.002	.009	3	2
URINARY_TRACT	TRIM51 →	+0.041	+4.217	<.001	.005	3	1
URINARY_TRACT	OPRPN →	+0.045	+4.087	<.001	.009	3	1
URINARY_TRACT	PRAMEF25 →	+0.010	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 556 associations by consensus.

C10orf71 by CDH6 expression — OESOPHAGUS

Explore this box plot interactively →