CDH5

Across TCGA patient cohorts, CDH5 mutation is significantly associated with the RNA expression of many other genes, with 2,985 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH5-associated genes across cancer lineages are OR8J1, MIR4708, and RNY3P12. Each is linked with CDH5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CDH5-to-partner and partner-to-CDH5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8J1 grouped by CDH5-low versus CDH5-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH5→partner) and Y-score (partner→CDH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OR8J1 →	+0.024	+4.883	<.001	.004	3	3
BRCA	MIR4708 →	+0.570	+7.731	<.001	.009	3	2
HNSC	RNY3P12 →	+0.365	+4.063	<.001	.004	3	2
HNSC	SNRPEP9 →	+0.142	+4.224	.002	.003	3	2
COAD	LYPLA1P1 →	+0.242	+5.087	<.001	.002	3	2
UCEC	FCER1A →	-0.720	-1.947	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,985 associations by consensus.

OR8J1 by CDH5 expression — HNSC

Explore this box plot interactively →