CDH4

Across TCGA patient cohorts, CDH4 protein abundance is significantly associated with the RNA expression of many other genes, with 4,341 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CDH4-associated genes across cancer lineages are SC5D, SLAMF1, and LYPD3. Each is linked with CDH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH4-to-partner and partner-to-CDH4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CDH4 versus SC5D in GBM, with a Pearson correlation of 0.37.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH4→partner) and Y-score (partner→CDH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SC5D →	+0.550	+0.486	.001	.002	3	2
CCRCC	SLAMF1 →	-0.557	-0.772	.006	.006	3	2
GBM	LYPD3 →	-0.309	-0.341	.004	.004	3	2
GBM	SLC25A23 →	+0.658	+0.422	<.001	<.001	3	2
GBM	RHPN2 →	+0.495	+0.386	.001	<.001	3	2
GBM	CNPY3 →	-0.294	-0.434	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,341 associations by consensus.

CDH4 vs SC5D — GBM

Explore this scatter interactively →