CDH4

Across TCGA pan-cancer cohorts, CDH4 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CDH4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CDH4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDH4 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

THCA, KIRC, and HNSC are the cancer types where CDH4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDH4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	+2.244	<.001	9	view →
KIRC	Female	All	+2.195	<.001	9	view →
HNSC	All	All	+0.731	<.001	9	view →
UCEC	All	II,III,IV	−1.657	<.001	6	view →
BRCA	All	III,IV	−0.746	<.001	6	view →
KIRP	All	II,III,IV	+1.223	.007	5	view →
COAD	Female	All	+0.161	.016	4	view →
CHOL	All	All	+0.847	.001	3	view →
KICH	Female	All	−0.438	.001	3	view →
LIHC	Male	All	−0.075	.011	3	view →
PRAD	All	All	−0.227	.014	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CDH4–THCA

Open the THCA breakdown →