CDH4

Across TCGA patient cohorts, CDH4 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH4-associated genes across cancer lineages are Caspase-7-cleavedD198, ATM, and Bad_pS112. Each is linked with CDH4 in more than 4 cancer types. Because this analysis shows association rather than direction, both CDH4-to-partner and partner-to-CDH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CDH4-low versus CDH4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH4→partner) and Y-score (partner→CDH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.807	+1.934	.001	.002	3	5
UCEC	ATM →	-0.445	-1.473	.001	.006	3	4
STAD	Bad_pS112 →	-0.176	-2.094	.033	.017	3	3
STAD	c-Kit →	-0.382	-3.321	.002	.009	3	3
STAD	4E-BP1 →	+0.356	+2.584	.002	.009	3	3
COAD	PAI-1 →	+0.435	+2.339	.023	.017	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

Caspase-7-cleavedD198 by CDH4 expression — COAD

Explore this box plot interactively →