CDH4

Across TCGA cell cohorts, CDH4 mutation is significantly associated with the RNA expression of many other genes, with 60 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH4-associated genes across cancer lineages are GABRR3, CLEC20A, and LUZP4. Each is linked with CDH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH4-to-partner and partner-to-CDH4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GABRR3 grouped by CDH4-low versus CDH4-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH4→partner) and Y-score (partner→CDH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GABRR3 →	+0.078	+4.017	.003	.007	3	1
OVARY	CLEC20A →	+0.074	+4.450	<.001	.004	3	1
LUNG_NSCLC_LUAD	LUZP4 →	+0.027	+2.478	<.001	.003	3	1
LUNG_NSCLC_LUAD	RGSL1 →	+0.037	+2.900	<.001	<.001	3	1
LUNG_NSCLC_LUAD	TDRD5 →	+0.873	+3.431	.001	.002	3	1
LUNG_NSCLC_LUAD	C1QTNF7 →	+0.041	+2.556	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

GABRR3 by CDH4 expression — OESOPHAGUS

Explore this box plot interactively →