CDH3

Across TCGA patient cohorts, CDH3 mutation is significantly associated with the RNA expression of many other genes, with 1,720 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH3-associated genes across cancer lineages are RN7SL568P, WASF2, and RRM1. Each is linked with CDH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDH3-to-partner and partner-to-CDH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL568P grouped by CDH3-low versus CDH3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH3→partner) and Y-score (partner→CDH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL568P →	+0.282	+3.486	<.001	.002	3	4
UCEC	WASF2 →	+0.499	+1.652	<.001	.006	3	2
UCEC	RRM1 →	+0.689	+3.191	<.001	<.001	3	2
UCEC	LETM1 →	+0.376	+1.864	.001	.004	3	2
UCEC	SNX11 →	+0.249	+1.992	.008	<.001	3	2
UCEC	RFC1 →	+0.454	+1.880	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,720 associations by consensus.

RN7SL568P by CDH3 expression — LUSC

Explore this box plot interactively →