CDH3

Across TCGA patient cohorts, CDH3 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH3-associated genes across cancer lineages are eIF4E, MSH6, and GSK3-a-b. Each is linked with CDH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CDH3-to-partner and partner-to-CDH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CDH3-low versus CDH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH3→partner) and Y-score (partner→CDH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.189	+2.662	.017	<.001	3	2
UCEC	MSH6 →	-0.469	-3.584	<.001	.002	3	2
BLCA	GSK3-a-b →	+0.195	+3.000	.021	.036	3	1
UCEC	14-3-3_beta →	-0.107	-3.432	.004	.005	3	1
UCEC	G6PD →	-0.309	-2.979	.010	<.001	3	1
UCEC	INPP4B →	-0.272	-2.584	.024	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

eIF4E by CDH3 expression — UCEC

Explore this box plot interactively →