CDH3

Across TCGA cell cohorts, CDH3 mutation is significantly associated with the mutation status of many other genes, with 5,646 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CDH3-associated genes across cancer lineages are RAPGEF1, ZNF534, and PCARE. Each is linked with CDH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDH3-to-partner and partner-to-CDH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAPGEF1 grouped by CDH3-low versus CDH3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH3→partner) and Y-score (partner→CDH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAPGEF1 →	+4.297	+4.857	.009	.009	1	4
BREAST	ZNF534 →	+5.297	+5.297	.004	.004	1	4
CNS	PCARE →	+3.877	+5.139	.001	.001	1	4
CNS	COL6A6 →	+2.614	+4.121	.009	.009	1	4
LUNG_NSCLC_LUAD	FLNB →	+2.924	+4.334	.006	.006	1	4
LARGE_INTESTINE	GLI1 →	+2.693	+2.989	<.001	<.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,646 associations by consensus.

RAPGEF1 by CDH3 expression — BREAST

Explore this box plot interactively →