CDH26

Across TCGA patient cohorts, CDH26 mutation is significantly associated with the RNA expression of many other genes, with 3,908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH26-associated genes across cancer lineages are LSM2, NDUFA12, and SAPCD2. Each is linked with CDH26 in more than 3 cancer types. Because this analysis shows association rather than direction, both CDH26-to-partner and partner-to-CDH26 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LSM2 grouped by CDH26-low versus CDH26-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH26→partner) and Y-score (partner→CDH26) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LSM2 →	+0.311	+2.233	.008	.005	3	4
COAD	NDUFA12 →	+0.453	+3.210	<.001	.009	3	3
UCEC	SAPCD2 →	+0.707	+1.890	<.001	<.001	3	3
UCEC	H2AX →	+0.438	+1.890	.001	.001	3	3
UCEC	BNIP3P1 →	+0.450	+2.681	<.001	<.001	3	3
UCEC	MCMBP →	+0.443	+1.691	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,908 associations by consensus.

LSM2 by CDH26 expression — UCEC

Explore this box plot interactively →