CDH26

Across TCGA pan-cancer cohorts, CDH26 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CDH26 data layer compared with 11 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CDH26 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CDH26 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

KIRP, LUAD, and LGG are the cancer types where CDH26 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	III,IV	0.106	0.573	<.001	68	view →
LUAD	OS	Median	All	0.423	0.265	<.001	66	view →
LGG	DFS	Median	All	0.645	0.823	<.001	54	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	45	view →
HNSC	OS	Median	All	0.805	0.697	.001	42	view →
PAAD	DFS	Tertile	II,III,IV	0.397	0.235	.001	38	view →
UVM	DFS	Median	III,IV	0.186	0.903	<.001	33	view →
ACC	OS	Median	All	0.935	0.403	.001	30	view →
COAD	DFS	Quartile	II,III,IV	0.694	0.887	.002	30	view →
SCLC	OS	Median	III,IV	0.176	0.463	.018	23	view →
SARC	OS	Tertile	All	0.582	0.396	.005	23	view →
CESC	OS	Median	II,III,IV	0.894	0.740	.010	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CDH26–KIRP (DFS)

Open the KIRP breakdown →