CDH23

Across TCGA pan-cancer cohorts, CDH23 Mutation is linked to patient survival in 13 of 34 cancer types, making it a survival-associated CDH23 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CDH23 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated CDH23 expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, ACC, and THCA are the cancer types where CDH23 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.925	0.295	.002	28	view →
ACC	DFS	Median	All	0.110	0.688	<.001	24	view →
THCA	DFS	Median	All	0.049	0.828	<.001	18	view →
OV	DFS	Median	II,III,IV	0.223	0.542	.004	18	view →
SCLC	DFS	Median	II,III,IV	0.240	0.627	.005	18	view →
STAD	DFS	Median	III,IV	1.000	0.550	.014	18	view →
BLCA	DFS	Median	All	0.147	0.603	<.001	15	view →
KIRP	DFS	Median	II,III,IV	0.167	0.793	<.001	9	view →
LUSC	DFS	Median	II,III,IV	0.284	0.607	.008	7	view →
LGG	OS	Median	All	0.493	0.892	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
COAD	OS	Median	IV	0.153	0.558	.043	3	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

CDH23–UCEC (DFS)

Open the UCEC breakdown →