CDH23

Across TCGA pan-cancer cohorts, CDH23 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CDH23’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CDH23 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CDH23 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

KIRC, LUAD, and COAD are the cancer types where CDH23 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CDH23 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.775	<.001	11	view →
LUAD	Male	II,III,IV	−0.960	<.001	9	view →
COAD	Male	All	−0.306	<.001	9	view →
UCEC	All	II,III,IV	−1.727	<.001	6	view →
BRCA	All	All	−1.167	<.001	6	view →
LUSC	Male	II,III,IV	−1.031	<.001	6	view →
CHOL	All	All	−0.957	<.001	5	view →
KICH	All	All	−0.395	<.001	5	view →
THCA	Female	All	−0.308	<.001	4	view →
READ	All	All	−0.387	.001	3	view →
PRAD	All	All	−0.559	<.001	2	view →
BLCA	Female	IV	+1.413	.004	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CDH23–KIRC

Open the KIRC breakdown →