CDH23

Across TCGA patient cohorts, CDH23 mutation is significantly associated with the RNA expression of many other genes, with 8,601 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CDH23-associated genes across cancer lineages are SUPV3L1, ZWINT, and EMC6. Each is linked with CDH23 in more than 5 cancer types. Because this analysis shows association rather than direction, both CDH23-to-partner and partner-to-CDH23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUPV3L1 grouped by CDH23-low versus CDH23-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CDH23→partner) and Y-score (partner→CDH23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SUPV3L1 →	+0.295	+2.760	<.001	<.001	3	6
LUAD	ZWINT →	+0.611	+1.426	.001	.006	3	5
UCEC	EMC6 →	+0.387	+1.263	<.001	.001	3	5
LUAD	PSMC3IP →	+0.515	+1.904	<.001	<.001	3	5
LUAD	POC1A →	+0.423	+1.904	.003	<.001	3	5
SKCM	HMG20B →	+0.369	+1.270	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,601 associations by consensus.

SUPV3L1 by CDH23 expression — LUAD

Explore this box plot interactively →